
This Spicy Mexican Casserole has transformed my weeknight dinner rotation with its bold flavors and comforting textures. The combination of savory ground beef, zesty spices, and crunchy tortilla chips creates a meal that satisfies even the pickiest eaters in my household.
I first made this casserole during a chaotic week when I needed something hearty that could feed my family for multiple meals. The way the tortilla chips soften slightly while maintaining their crunch around the edges creates a texture that keeps everyone coming back for seconds.
Ingredients
- Ground beef: Adds hearty protein and savory flavor. Look for 80/20 lean to fat ratio for best flavor
- Onion: Provides aromatic base that builds depth. Choose sweet yellow varieties for milder flavor
- Diced tomatoes with green chilies: Brings instant heat and acidity. Rotel brand works perfectly here
- Cream soups: Create a rich binding sauce. The combination of mushroom and chicken adds complexity
- Corn: Adds sweet pops of texture. Fresh corn cut from the cob works beautifully in summer
- Black beans: Provide protein and earthiness. Rinse well to remove excess sodium
- Tortilla chips: Create the crunchy topping and base. Thicker restaurant-style chips hold up best
- Mexican cheese blend: Melts beautifully. Freshly grated melts more evenly than pre-shredded
- Sour cream: Adds cooling creaminess. Full-fat creates the best texture
- Spices: Like cumin, chili, and garlic powder create authentic Mexican flavor profile
Step-by-Step Instructions
- Prepare Your Baking Dish:
- Preheat your oven to 350°F making sure your rack is positioned in the middle. Take time to properly grease your 9x13 baking dish ensuring the corners get a light coating to prevent sticking.
- Cook The Meat Mixture:
- Brown your ground beef in a large skillet over medium heat breaking it into small pieces with a wooden spoon. Add the diced onion when the beef is about halfway cooked. Continue cooking until no pink remains in the meat and the onions have become translucent and soft, about 8 minutes total. Drain any excess fat carefully.
- Build The Flavor Base:
- Add all your canned ingredients and spices to the meat mixture. The tomatoes with their juice, the drained corn, the rinsed black beans, and both cream soups get stirred in thoroughly. Season with garlic powder, chili powder, cumin, salt, and pepper. Let everything simmer together for about 3 minutes allowing the flavors to meld.
- Create The Casserole Layers:
- Crush the tortilla chips while still in their bag, then spread half across the bottom of your prepared baking dish. They should form an even layer that completely covers the bottom. Pour your meat mixture over the chips carefully, spreading it to the edges. The bottom layer of chips will begin to soften slightly from the moisture.
- Add The Finishing Touches:
- Sprinkle the remaining crushed tortilla chips over the meat layer creating a textural contrast. Cover everything with an even layer of shredded Mexican cheese blend making sure to reach the edges where cheese will create delicious crispy bits during baking.
- Bake To Perfection:
- Place your casserole in the preheated oven and bake uncovered for 25 to 30 minutes. Look for bubbling around the edges and a golden brown cheese top. The casserole should be hot throughout with the cheese completely melted.
- Rest And Serve:
- Allow the casserole to rest for 5 to 7 minutes after removing from the oven. This crucial step helps the layers set so you can get clean portions. Serve with a dollop of sour cream on top and fresh chopped cilantro for brightness.

The secret to making this casserole truly special lies in toasting your spices with the meat mixture. When I add the cumin, chili powder and garlic powder, I let them cook with the meat for about 30 seconds before adding the wet ingredients. This simple step releases their aromatic oils and creates a much deeper flavor profile that elevates the entire dish.
Storage And Reheating
This casserole maintains its quality when stored properly in the refrigerator for up to 4 days. Cover leftovers tightly with plastic wrap or transfer to airtight containers. For best results when reheating individual portions use the microwave for 2 minutes covered with a damp paper towel to prevent drying. For larger portions reheat covered with foil in a 325°F oven for about 20 minutes until heated through.
Smart Substitutions
This recipe welcomes creative adaptations based on what you have available. Ground turkey or chicken works beautifully in place of beef for a lighter option. Vegetarians can substitute an additional can of beans or crumbled firm tofu seasoned with taco spices. If you prefer to avoid canned soups create a simple roux with butter, flour, and milk then season accordingly. For gluten free versions confirm your cream soups are compliant and use corn tortilla chips.
Serving Suggestions
Transform this casserole into an impressive spread by serving it alongside complementary sides. A simple green salad dressed with lime vinaigrette provides freshness that balances the rich casserole. Offer toppings like diced avocado, fresh pico de gallo, or pickled jalapeños for guests to customize their portions. For entertaining serve with margaritas or Mexican beer with lime wedges for an authentic fiesta experience.
Frequently Asked Questions
- → Can I substitute ground beef with another protein?
Yes, you can use ground turkey, chicken, or even a plant-based alternative like lentils or soy crumbles.
- → How can I make this dish spicier?
Increase the chili powder or add diced jalapeños for extra heat. Hot sauce or cayenne pepper also works well.
- → Can I make it ahead of time?
Absolutely! Assemble the casserole, cover it tightly, and refrigerate for up to 24 hours. Bake when ready.
- → Can I use something other than tortilla chips?
Crushed corn chips, panko breadcrumbs, or even crushed crackers can work as a substitution for tortilla chips.
- → How do I store leftovers?
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the oven or microwave.